A clean separation is half of a successful plate. Here are the basics to prepare a flexo file with no nasty surprises.
Make sure no RGB remains and that spot colors (Pantone) are named properly and merged when duplicated. One forgotten spot color means one plate too many.
On film or non-white substrates, the printing white is a dedicated spot color. It "carries" the colors — don't forget it.
Before the proof, open the separations one by one. It's the only way to catch text sent to the wrong channel. Two minutes of checking saves hours.