In prepress, people often think everything happens on screen. In reality, a good file starts with a solid understanding of the press that will print it.
Every process — flexo, offset, digital — has its own constraints: dot gain, registration play, maximum screen ruling, compatible inks and substrates. Preparing a file without these is working blind.
Before separating or imposing anything, fill in a "machine" sheet: substrate, process, ruling, curve, registration. That one document prevents most reworks and re-plates.
This is the starting point of level 1 of my training: Know your machine.